3α,5α-Tetrahydronorethisterone

• Catalog No.: T294135
• CAS Number: 16392-60-2
• M. F.: C20H30O2
• M. W.: 302.451

SYNONYMS

• IUPAC name: (1R,2S,5R,7S,10R,11S,14R,15S)-14-ethynyl-15-methyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecane-5,14-diol
• IUPAC Traditional name: (1R,2S,5R,7S,10R,11S,14R,15S)-14-ethynyl-15-methyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecane-5,14-diol
• Synonyms: (3α,5α,17α)-19-Norpregn-20-yne-3,17-diol; 19-Nor-5α,17α-pregn-20-yne-3α,17-diol; 17α-Ethynyl-5α-oestrane-3α,17β-diol; 17α-Ethynyl-5α-estrane-3α,17β-diol

DATABASE IDS

• CAS Number: 16392-60-2

DETAILS

Description (English)

A 3α-metabolite of progesterone receptor agonist Norethindrone (N676000) that acts as a estrogen receptor in osteoblastic cells. It also has novel nongenomic endothelium-independent vasorelaxing effects.

REFERENCES

• Lemus, A.E. et al.: J. Endocrinol., 200, 199 (2009)
• Perusquia, M. et al.: Eur. J. Pharmacol., 475, 161 (2009)
• Blom, M.J. et al.: Drug Metab. Disp., 29, 976 (2009)