Teicoplanin

• Catalog No.: T015500
• CAS Number: 91032-26-7
• M. F.: C88H97Cl2N9O33
• M. W.: 1879.65828
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (1S,2R,19R,22R,34S,37R,40R,52S)-22-amino-5,63-dichloro-64-{[(2S,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(8-methylnonanamido)oxan-2-yl]oxy}-2-{[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-26,31,44,49-tetrahydroxy-21,35,38,54,56,59-hexaoxo-47-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-7,13,28-trioxa-20,36,39,53,55,58-hexaazaundecacyclo[38.14.2.2^3,^6.2^1^4,^1^7.2^1^9,^3^4.1^8,^1^2.1^2^3,^2^7.1^2^9,^3^3.1^4^1,^4^5.0^1^0,^3^7.0^4^6,^5^1]hexahexaconta-3,5,8,10,12(64),14,16,23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49,62,65-henicosaene-52-carboxylic acid
• IUPAC Traditional name: (1S,2R,19R,22R,34S,37R,40R,52S)-22-amino-5,63-dichloro-64-{[(2S,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(8-methylnonanamido)oxan-2-yl]oxy}-2-{[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-26,31,44,49-tetrahydroxy-21,35,38,54,56,59-hexaoxo-47-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-7,13,28-trioxa-20,36,39,53,55,58-hexaazaundecacyclo[38.14.2.2^3,^6.2^1^4,^1^7.2^1^9,^3^4.1^8,^1^2.1^2^3,^2^7.1^2^9,^3^3.1^4^1,^4^5.0^1^0,^3^7.0^4^6,^5^1]hexahexaconta-3,5,8,10,12(64),14,16,23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49,62,65-henicosaene-52-carboxylic acid
• Synonyms: Targosid; Teicoplanin A2; MDL-507; Targocid; Teichomycin A2

DATABASE IDS

• CAS Number: 91032-26-7

PROPERTIES

• Apperance: White Amorphous Powder
• Melting Point: 250°C (dec.)
• Solubility: Ethanol
• Solubility: Methanol
• Solubility: Water
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

Glycopeptide antibiotic complex produced by Actinoplanes teichomyceticus; structurally related to vancomycin. Comprised of 5 major components differentiated by a specific fatty acid moiety. Inhibits peptidoglycan synthesis in the cell wall of gram-positiv

REFERENCES

• Cynamon, M.H., et al.: Antimicrob. Agents Chemother., 21, 504 (1982)
• Williams, A.H., et al.: J. Antimicrob. Chemother., 14, 441 (1982)
• Dunayevskiy, Y., et al.: J. Med. Chem., 41, 1201 (1982)
• Chinchilla, D., et al.: Anal. Bioanal. Chem., 383, 625 (2005)