Taurodeoxycholic-2,2,3,4,4-d5 Acid (d5 major)

• Catalog No.: T009002
• M. F.: C26H45NO6S
• M. W.: 499.7036
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 2-[(4R)-4-[(1S,2S,5R,7R,10R,11S,14R,15R,16S)-5,16-dihydroxy-2,15-dimethyl(4,4,5,6,6-^2H₅)tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecan-14-yl]pentanamido]ethane-1-sulfonic acid
• IUPAC Traditional name: 2-[(4R)-4-[(1S,2S,5R,7R,10R,11S,14R,15R,16S)-5,16-dihydroxy-2,15-dimethyl(4,4,5,6,6-^2H₅)tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecan-14-yl]pentanamido]ethanesulfonic acid
• Synonyms: 2-[[(3α,5β,12β)-3,12-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic Acid-d5; Deoxytaurocholic-d5 Acid; Taurodesoxycholic-d5 Acid; Tudcabil-d5; N-(3α,12α-Dihydroxy-5β-cholan-24-oyl)taurine-d5; Deoxycholyltaurine-d5

PROPERTIES

• Apperance: White Solid
• Melting Point: >170°C (dec.)
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.

REFERENCES

• Cheng, K., et al.: Biochem. J., 330, 353 (1998)
• Cheng, K., et al.: Cancer Res., 63, 6744 (1998)
• Bellacosa, A., et al.: Adv. Cancer Res., 94, 29 (1998)
• Cheng, K., et al.: Biochem. Pharmacol., 70, 1035 (1998)
• Fang, D., et al.: J. Biol. Chem., 282, 11221