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Tamoxifen N-Oxide

Catalog No. T006095 Name Toronto Research Chemicals
CAS Number 75504-34-6 Website http://www.trc-canada.com
M. F. C26H29NO2 Telephone +1 (416) 665-9696
M. W. 387.51396 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Amber Vial, -20°C Freezer, Under Inert Atmosphere Chembase ID: 178062

SYNONYMS

IUPAC name
1-[2-(dimethyl-oxo-$l^{5}-azanyl)ethoxy]-4-[(1Z)-1,2-diphenylbut-1-en-1-yl]benzene
IUPAC Traditional name
tamoxifen N-oxide
Synonyms
(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine N-Oxide

DATABASE IDS

CAS Number 75504-34-6

PROPERTIES

Certificate of Analysis Download
Apperance White Solid
Melting Point 136-141°C
Solubility Chloroform
Solubility Methanol
MSDS Link Download
Storage Condition Amber Vial, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)
A metabolite of Tamoxifen (T006000), a nonsteroidal estrogen antagonist of interest in the treatment of some forms of breast cancer. Tamoxifen is a Protein Kinase C inhibitor, and induces apoptosis in human malignant glioma cell lines.

REFERENCES

  • Brandt, S., et al.: Anticancer Res., 23, 223 (2003)
  • Coller, J., et al.: Br. J. Clin. Pharmacol., 57, 105 (2003)
  • Parte, P., et al.: Drug Metab. Dispos., 33, 1446 (2003)