Tamoxifen N-Oxide

• Catalog No.: T006095
• CAS Number: 75504-34-6
• M. F.: C26H29NO2
• M. W.: 387.51396
• Storage: Amber Vial, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: 1-[2-(dimethyl-oxo-$l^{5}-azanyl)ethoxy]-4-[(1Z)-1,2-diphenylbut-1-en-1-yl]benzene
• IUPAC Traditional name: tamoxifen N-oxide
• Synonyms: (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine N-Oxide

DATABASE IDS

• CAS Number: 75504-34-6

PROPERTIES

• Apperance: White Solid
• Melting Point: 136-141°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: Amber Vial, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A metabolite of Tamoxifen (T006000), a nonsteroidal estrogen antagonist of interest in the treatment of some forms of breast cancer. Tamoxifen is a Protein Kinase C inhibitor, and induces apoptosis in human malignant glioma cell lines.

REFERENCES

• Brandt, S., et al.: Anticancer Res., 23, 223 (2003)
• Coller, J., et al.: Br. J. Clin. Pharmacol., 57, 105 (2003)
• Parte, P., et al.: Drug Metab. Dispos., 33, 1446 (2003)