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Tabimorelin

Catalog No. T003500 Name Toronto Research Chemicals
CAS Number 193079-69-5 Website http://www.trc-canada.com
M. F. C32H40N4O3 Telephone +1 (416) 665-9696
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SYNONYMS

IUPAC name
(2E)-5-amino-N,5-dimethyl-N-[(1R)-1-{methyl[(1R)-1-(methylcarbamoyl)-2-phenylethyl]carbamoyl}-2-(naphthalen-2-yl)ethyl]hex-2-enamide
IUPAC Traditional name
(2E)-5-amino-N,5-dimethyl-N-[(1R)-1-{methyl[(1R)-1-(methylcarbamoyl)-2-phenylethyl]carbamoyl}-2-(naphthalen-2-yl)ethyl]hex-2-enamide
Synonyms
NNC 26-0703
NN 703
N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-Dimethyl-D-phenylalaninamide

DATABASE IDS

CAS Number 193079-69-5

PROPERTIES

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DETAILS

Description (English)
NN703 (Tabimorelin) is an orally active growth hormone (GH) secretagogue intended for use as an alternative to daily injections of GH. In vitro studies in human liver microsomes have indicated that NN703 is a mechanism-based inhibitor of CYP3A4.

REFERENCES

  • Fabre, G., et al.: Biochem. Pharmacol., 37, 4389 (1988)
  • Thummel, K., et al.: Clin. Pharmacol. Ther., 59, 491 (1988)
  • Yu, D., et al.: J. Clin. Pharmacol., 39, 1203 (1988)