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Swainsonine

Catalog No. S885000 Name Toronto Research Chemicals
CAS Number 72741-87-8 Website http://www.trc-canada.com
M. F. C8H15NO3 Telephone +1 (416) 665-9696
M. W. 173.2096 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage -20°C Freezer Chembase ID: 129676

SYNONYMS

IUPAC name
(1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol
IUPAC Traditional name
swainsonine
Synonyms
8α,β-Octahydroindolizidine-1α,2α,8β-triol
(-)-Swainsonine
Tridolgosir

DATABASE IDS

CAS Number 72741-87-8

PROPERTIES

Certificate of Analysis Download
Apperance White to Off-White Solid
Melting Point >125°C (dec.)
Solubility DMSO
Solubility Methanol
Solubility Water
MSDS Link Download
Storage Condition -20°C Freezer

DETAILS

Description (English)
Swainsonine is a plant alkaloid derived from Swainsona canescens (a leguminous plant). It is a reversible, active-site directed inhibitor of a-mannosidase at concentrations of 5-10mM. At acid pH, swainsonine resembles an intermediate in the hydrolysis of

REFERENCES

  • J. Biol. Chem., 258, 7578-7585 (1983)
  • Methods Enzymol., 98, 135 (1983)
  • EMBO Journal, 3, 551-556 (1983)
  • Mol. Cell. Biol., 5, 3467-3475 (1983)
  • Int. J. Cancer, 44, 685 (1983)
  • Melanoma Res., 1, 43 (1983)
  • Bonay, P., & Fresno, M.: Glycobiology, 9(1983)
  • 423-4