Sulindac Sulfide

• Catalog No.: S699220
• CAS Number: 49627-27-2
• M. F.: C20H17FO2S
• M. W.: 340.4111832
• Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere

SYNONYMS

• IUPAC name: 2-[(1Z)-5-fluoro-2-methyl-1-{[4-(methylsulfanyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid
• IUPAC Traditional name: [(3Z)-6-fluoro-2-methyl-3-{[4-(methylsulfanyl)phenyl]methylidene}inden-1-yl]acetic acid
• Synonyms: (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid

DATABASE IDS

• CAS Number: 49627-27-2

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: 177-182°C
• Solubility: Acetone
• Solubility: Dichloromethane
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under inert atmosphere

DETAILS

Description (English)

An active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120

REFERENCES

• Hermann, C., et al.: Oncogene, 17, 1769 (1998)
• Lim, T.J., et al.: Biochem. Pharmacol., 58, 1097 (1998)
• Zhang, Z. and DuBois, R.N.: Gastroenterology, 118, 1012 (1998)