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Sulindac Sulfide

Catalog No. S699220 Name Toronto Research Chemicals
CAS Number 49627-27-2 Website http://www.trc-canada.com
M. F. C20H17FO2S Telephone +1 (416) 665-9696
M. W. 340.4111832 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Hygroscopic, -20°C Freezer, Under inert atmosphere Chembase ID: 132926

SYNONYMS

IUPAC name
2-[(1Z)-5-fluoro-2-methyl-1-{[4-(methylsulfanyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid
IUPAC Traditional name
[(3Z)-6-fluoro-2-methyl-3-{[4-(methylsulfanyl)phenyl]methylidene}inden-1-yl]acetic acid
Synonyms
(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid

DATABASE IDS

CAS Number 49627-27-2

PROPERTIES

Certificate of Analysis Download
Apperance Yellow Solid
Melting Point 177-182°C
Solubility Acetone
Solubility Dichloromethane
Solubility DMSO
Solubility Methanol
MSDS Link Download
Storage Condition Hygroscopic, -20°C Freezer, Under inert atmosphere

DETAILS

Description (English)
An active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120

REFERENCES

  • Hermann, C., et al.: Oncogene, 17, 1769 (1998)
  • Lim, T.J., et al.: Biochem. Pharmacol., 58, 1097 (1998)
  • Zhang, Z. and DuBois, R.N.: Gastroenterology, 118, 1012 (1998)