N-Succinimidoxycarbonyl-β-alanine N-Succinimidyl Ester 1,4- Dioxane complex

• Catalog No.: S689850
• CAS Number: 1215667-16-5
• M. F.: C16H21N3O10
• M. W.: 415.35204
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: 1,4-dioxane 2,5-dioxopyrrolidin-1-yl 3-({[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}amino)propanoate
• IUPAC Traditional name: dioxane 2,5-dioxopyrrolidin-1-yl 3-({[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}amino)propanoate
• Synonyms: N-[[N-[(Succinimidooxy)carbonyl]-β-alanyl]oxy]succinimide 1,4- Dioxane

DATABASE IDS

• CAS Number: 1215667-16-5

PROPERTIES

• Apperance: White Solid
• Melting Point: 163-164°C
• Solubility: DMSO
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A short, amino reactive homobifunctional crosslinking reagent. Crosslinking distance 8.3 Å. It is useful in polymer coupling to proteins, because it may lead to a better selectivity among all the amino groups present in a protein, thus yielding less heterogeneous PEG-protein conjugates mixture because only the most nucleophilic and solvent exposed amines can react.

REFERENCES

• Gross, H., et al.: Tetrahedron, 24, 6935 (1968)
• Clark, R., et al.: J. Biol. Chem., 271, 21969 (1968)
• Guiotto, A., et al.: Bioorg. Med. Chem., 12, 5031 (1968)