N-Succinimidoxycarbonyl-β-alanine N-Succinimidyl Ester

• Catalog No.: S689840
• CAS Number: 21994-89-8
• M. F.: C12H13N3O8
• M. W.: 327.24692

SYNONYMS

• IUPAC name: 2,5-dioxopyrrolidin-1-yl 3-({[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}amino)propanoate
• IUPAC Traditional name: 2,5-dioxopyrrolidin-1-yl 3-({[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}amino)propanoate
• Synonyms: N-[[N-[(Succinimidooxy)carbonyl]-β-alanyl]oxy]succinimide; 1-[3-[[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]amino]-1-oxopropoxy]-2,5-pyrrolidinedione; N-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]-β-alanine 2,5-Dioxo-1-pyrrolidinyl Ester

DATABASE IDS

• CAS Number: 21994-89-8

DETAILS

Description (English)

A short, amino reactive homobifunctional crosslinking reagent. Crosslinking distance 8.3 Å. It is useful in polymer coupling to proteins, because it may lead to a better selectivity among all the amino groups present in a protein, thus yielding less heterogeneous PEG-protein conjugates mixture because only the most nucleophilic and solvent exposed amines can react.

REFERENCES

• Gross, H., et al.: Tetrahedron, 24, 6935 (1968)
• Clark, R., et al.: J. Biol. Chem., 271, 21969 (1968)
• Guiotto, A., et al.: Bioorg. Med. Chem., 12, 5031 (1968)