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SU 5402

Catalog No. S688000 Name Toronto Research Chemicals
CAS Number 215543-92-3 Website http://www.trc-canada.com
M. F. C17H16N2O3 Telephone +1 (416) 665-9696
M. W. 296.32054 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage -20°C Freezer Chembase ID: 6185

SYNONYMS

IUPAC name
3-(4-methyl-2-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid
IUPAC Traditional name
3-(4-methyl-2-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid
Synonyms
3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone
2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic Acid

DATABASE IDS

CAS Number 215543-92-3

PROPERTIES

Certificate of Analysis Download
Apperance Yellow-Green Solid
Melting Point >222°C (dec.)
Solubility DMSO
Solubility Methanol
MSDS Link Download
Storage Condition -20°C Freezer

DETAILS

Description (English)
A specific FGFR (fibroblast growth factor receptor) inhibitor. An intermediate for 3-(hetero)arylmethylidene-2-indolinone derivatives as modulators of protein kinase activity for use in treating cancer.

REFERENCES

  • Panek, R., et al.: J. Pharmacol. Exp. Ther., 286, 569 (1998)
  • Cronauer, M., et al.: Eur. Urol., 43, 309 (1998)
  • Pao, W., et al.: J. Clin. Oncol., 23, 2556 (1998)
  • Korynevska, A., et al.: Biochem. Pharmacol., 74, 1713 (1998)
  • Li, T., et al.: Clin. Cancer R