SU 5402

• Catalog No.: S688000
• CAS Number: 215543-92-3
• M. F.: C17H16N2O3
• M. W.: 296.32054
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 3-(4-methyl-2-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid
• IUPAC Traditional name: 3-(4-methyl-2-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid
• Synonyms: 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone; 2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic Acid

DATABASE IDS

• CAS Number: 215543-92-3

PROPERTIES

• Apperance: Yellow-Green Solid
• Melting Point: >222°C (dec.)
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A specific FGFR (fibroblast growth factor receptor) inhibitor. An intermediate for 3-(hetero)arylmethylidene-2-indolinone derivatives as modulators of protein kinase activity for use in treating cancer.

REFERENCES

• Panek, R., et al.: J. Pharmacol. Exp. Ther., 286, 569 (1998)
• Cronauer, M., et al.: Eur. Urol., 43, 309 (1998)
• Pao, W., et al.: J. Clin. Oncol., 23, 2556 (1998)
• Korynevska, A., et al.: Biochem. Pharmacol., 74, 1713 (1998)
• Li, T., et al.: Clin. Cancer R