STn Epitope N-Acetate

• Catalog No.: S687050
• CAS Number: 385398-89-0
• M. F.: C24H39N3O17
• M. W.: 641.57636

SYNONYMS

• IUPAC name: (2R,4S,5R,6R)-2-{[(2R,3R,4R,5R,6S)-6-[(2S)-2-carboxy-2-acetamidoethoxy]-5-acetamido-3,4-dihydroxyoxan-2-yl]methoxy}-5-acetamido-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
• IUPAC Traditional name: (2R,4S,5R,6R)-2-{[(2R,3R,4R,5R,6S)-6-[(2S)-2-carboxy-2-acetamidoethoxy]-5-acetamido-3,4-dihydroxyoxan-2-yl]methoxy}-5-acetamido-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
• Synonyms: 6-O-α-Sialyl-2-acetamido-2-deoxy-α-D-galactopyranosyl-1-O-L-serine N-Acetate; N-Acetyl-O-[2-(acetylamino)-6-O-(N-acetyl-α-neuraminosyl)-2-deoxy-α-D-galactopyranosyl]-L-serine

DATABASE IDS

• CAS Number: 385398-89-0

PROPERTIES

• Apperance: Off-White Amorphous Solid
• Solubility: Warm Methanol
• Solubility: Water
• Storage Warning: Moisture Sensitive

DETAILS

Description (English)

Sialosyl-Tn epitope is a cancer associated carbohydrate antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. These antigens appear as clusters of glycopeptide repea

REFERENCES

• Kim, J.M., and Roy, R.: Tetrahedron Lett., 38, 3487 (1997)
• Qiu, D., and Koganty, R.: Tetrahedron Lett., 38, 961 (1997)
• Toyokuni, T., and Singhal, A.K.: Chem. Soc. Rev., 231, (1995)