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SN-38

Catalog No. S589950 Name Toronto Research Chemicals
CAS Number 86639-52-3 Website http://www.trc-canada.com
M. F. C22H20N2O5 Telephone +1 (416) 665-9696
M. W. 392.4046 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage -20°C Freezer Chembase ID: 129497

SYNONYMS

IUPAC name
(19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
IUPAC Traditional name
(19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
Synonyms
(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
7-Ethyl-10-hydroxycamptothecin
10-Hydroxy-7-ethylcamptothecin
SN 38 Lactone

DATABASE IDS

CAS Number 86639-52-3

PROPERTIES

Certificate of Analysis Download
Apperance Light-Yellow Solid
Melting Point 218-221°C dec.
Solubility DMSO
MSDS Link Download
Storage Condition -20°C Freezer

DETAILS

Description (English)
A metabolite of Irinotecan, a DNA topoisomerase inhibitor.

REFERENCES

  • Billecke, S., et al.: Drug Metab. Dispos., 28, 1335 (2000)
  • Teiber, J., et al.: Biochem. Pharmacol., 66, 887 (2000)
  • Ashley, G., et al.: J. Antibiot., 57, 224 (2000)