SN-38

• Catalog No.: S589950
• CAS Number: 86639-52-3
• M. F.: C22H20N2O5
• M. W.: 392.4046
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• IUPAC Traditional name: (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• Synonyms: (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione; 7-Ethyl-10-hydroxycamptothecin; 10-Hydroxy-7-ethylcamptothecin; SN 38 Lactone

DATABASE IDS

• CAS Number: 86639-52-3

PROPERTIES

• Apperance: Light-Yellow Solid
• Melting Point: 218-221°C dec.
• Solubility: DMSO
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A metabolite of Irinotecan, a DNA topoisomerase inhibitor.

REFERENCES

• Billecke, S., et al.: Drug Metab. Dispos., 28, 1335 (2000)
• Teiber, J., et al.: Biochem. Pharmacol., 66, 887 (2000)
• Ashley, G., et al.: J. Antibiot., 57, 224 (2000)