SKF-525A Hydrochloride

• Catalog No.: S550000
• CAS Number: 62-68-0
• M. F.: C23H32ClNO2
• M. W.: 389.95868
• Storage: Refrigerator, Under Inert Atmosphere

SYNONYMS

• IUPAC name: 2-(diethylamino)ethyl 2,2-diphenylpentanoate hydrochloride
• IUPAC Traditional name: proadifen hydrochloride
• Synonyms: 2-(Diethylamino)ethyl 2,2-Diphenylvalerate Hydrochloride; RP 5171; Proadifen Hydrochloride; 2,2-Diphenylvaleric Acid 2-(Diethylamino)ethyl Ester Hydrochloride; α-Phenyl-α-Propylbenzeneacetic Acid 2-(Diethylamino)ethyl Ester Hydrochloride; SKF 525; U 5446

DATABASE IDS

• CAS Number: 62-68-0

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 122-123°C
• Solubility: Methanol
• Solubility: Water
• Storage Condition: Refrigerator, Under Inert Atmosphere
• Storage Warning: Store in Freezer

DETAILS

Description (English)

Cytochrome P-459 inhibitor; blocks glibenclamide-sensitive K+ channels; inhibits neuronal nitric oxide synthetase; stimulates endothelial cell prostacyclin while inhibiting platelet thromboxane synthesis.

REFERENCES

• Boeynaems, J.M., et al.: Prostaglandins Leukotrienes Med., 25, 123 (1986)
• Khan, S., et al.: Biochem. Pharmacol., 45, 439 (1986)
• Salvemini, D., et al.: Br. J. Pharmacol., 108, 162 (1986)
• Satoh, T., et al.: J. Clin. Invest., 91, 409 (1993)