Sitagliptin-d4 Phosphate

• Catalog No.: S491002
• M. F.: C16H16F6N5O5P
• M. W.: 503.2929202
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (3R)-3-amino-1-[3-(trifluoromethyl)(5,5,6,6-^2H₄)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one phosphoperoxol hydrogen
• IUPAC Traditional name: (3R)-3-amino-1-[3-(trifluoromethyl)(5,5,6,6-^2H₄)-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one phosphoperoxol hydrogen
• Synonyms: MK 0431-d4; 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine-d4 Phosphate; Januvia-d4

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 193-195°C
• Solubility: Methanol
• Solubility: Water
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.

REFERENCES

• Kim, D., et al.: J. Med. Chem., 48, 141 (2005)
• Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005)
• Bergman, A., et al: Clin. Ther., 28, 55 (2006).