Simvastatin-d6 Hydroxy Acid Ammonium Salt

• Catalog No.: S485022
• M. F.: C25H43NO6
• M. W.: 453.61202
• Storage: -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: ammonium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-{[2,2-bis(^2H₃)methylbutanoyl]oxy}-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
• IUPAC Traditional name: ammonium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-{[2,2-bis(^2H₃)methylbutanoyl]oxy}-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
• Synonyms: (βR,δR,1S,2S,6R,8S,8aR)-8-[2,2-(Dimethyl-d6)-1-oxobutoxy]-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic Acid Ammonium Salt; Simvastatin-d6 Ammonium Salt; Simvastatin-d6 Carboxylic Acid Ammonium Salt; Simvastatin-d6 Acid Ammonium Salt

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 150-153°C
• Solubility: DMSO
• Solubility: Ethanol
• Solubility: Methanol
• Solubility: Water
• Storage Condition: -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A deuterated metabolite of Simvastin (S485000). A competitive inhibitor of HMG-CoA reductase.

REFERENCES

• Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986)
• Mol, M.J., et al.: Lancet, 2, 936 (1986)