Simvastatin Hydroxy Acid Ammonium Salt

• Catalog No.: S485020
• CAS Number: 139893-43-9
• M. F.: C25H43NO6
• M. W.: 453.61202
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: ammonium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
• IUPAC Traditional name: ammonium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
• Synonyms: Simvastatin Ammonium Salt; (βR,δR,1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic Acid Ammonium Salt; Simvastatin Carboxylic Acid Ammonium Salt; Simvastatin Acid Ammonium Salt

DATABASE IDS

• CAS Number: 139893-43-9

PROPERTIES

• Apperance: White Solid
• Melting Point: 128-131°C
• Solubility: DMSO
• Solubility: Ethanol
• Solubility: Methanol
• Solubility: Water
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A metabolite of Simvastin (S485000). A competitive inhibitor of HMG-CoA reductase.

REFERENCES

• Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986)
• Mol, M.J., et al.: Lancet, 2, 936 (1986)