Simvastatin-d6

• Catalog No.: S485002
• M. F.: C25H38O5
• M. W.: 418.56622
• Storage: -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-bis(^2H₃)methylbutanoate
• IUPAC Traditional name: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-bis(^2H₃)methylbutanoate
• Synonyms: Cholestat-d6; Novo-Simvastatin-d6; Sinvacor-d6; Statin-d6; Zocor-d6; 2,2-(Dimethyl-d6)butanoic Acid(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester; (+)-Simvastatin-d6; Lipex-d6; Simvotin-d6; Zorced-d6

PROPERTIES

• Apperance: White Solid
• Melting Point: 117-120°C
• Solubility: Dichloromethane
• Solubility: DMF
• Solubility: DMSO
• Solubility: Ether
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Storage Condition: -20°C Freezer, Under Inert Atmosphere
• Storage Warning: Hygroscopic

DETAILS

Description (English)

Deuterated Simvastatin, a competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic.

REFERENCES

• Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986)
• Mol, M.J., et al.: Lancet, 2, 936 (1986)