Simvastatin

• Catalog No.: S485000
• CAS Number: 79902-63-9
• M. F.: C25H38O5
• M. W.: 418.56622
• Storage: -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
• IUPAC Traditional name: simvastatin
• Synonyms: (+)-Simvastatin; 2,2-Dimethylbutanoic Acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester; Simvotin; Lipex; Statin; Zocor; Cholestat; Novo-Simvastatin; Sinvacor; Zorced

DATABASE IDS

• CAS Number: 79902-63-9

PROPERTIES

• Apperance: White Powder
• Melting Point: 123-125°C
• Solubility: Dichloromethane
• Solubility: Ether
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Storage Condition: -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

Simvastatin is a synthetic derivate of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.

REFERENCES

• Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986)
• Mol, M.J., et al.: Lancet, 2, 936 (1986)