Scriptide

• Catalog No.: S201500
• CAS Number: 287383-59-9
• M. F.: C18H18N2O4
• M. W.: 326.34652

SYNONYMS

• IUPAC name: 6-{2,4-dioxo-3-azatricyclo[7.3.1.0^5,^1^3]trideca-1(13),5,7,9,11-pentaen-3-yl}-N-hydroxyhexanamide
• IUPAC Traditional name: 6-{2,4-dioxo-3-azatricyclo[7.3.1.0^5,^1^3]trideca-1(13),5,7,9,11-pentaen-3-yl}-N-hydroxyhexanamide
• Synonyms: GCK 1026; N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide

DATABASE IDS

• CAS Number: 287383-59-9

DETAILS

Description (English)

Histone deacetylase inhibitor. A cell-permeable, relatively non-toxic HDAC inhibitor that facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient receptor assays in a concentration-dependent manner.

REFERENCES

• Won, J., et al.: Proc. Natl. Acad. Sci., 101, 11328 (2004)
• Su, G.H., et al.: Cancer Res., 60, 3137 (2004)
• Backs, J., et al.: J. Clin. Invest. 116, 1853 (2004)
• Fath, D., et al.: J. Biol. Chem., 281, 13612 (2004)