Saxagliptin-13C3

• Catalog No.: S143502
• M. F.: C18H25N3O2
• M. W.: 318.38796451

SYNONYMS

• IUPAC name: (1R,3R,5S)-2-[(2S)-2-amino-2-[(1r,3R,5R,7S)-3-hydroxyadamantan-1-yl](1,2-^1^3C₂)acetyl](6-^1^3C)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
• IUPAC Traditional name: (1R,3R,5S)-2-[(2S)-2-amino-2-[(1r,3R,5R,7S)-3-hydroxyadamantan-1-yl](1,2-^1^3C₂)acetyl](6-^1^3C)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
• Synonyms: (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile-13C3; BMS 477118-13C3; Onglyza-13C3; BMS 477118-11-13C3

DETAILS

Description (English)

Labelled Saxagliptin. It is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible

REFERENCES

• Feng, J., et al.: J. Med. Chem., 50, 2297 (2007)
• Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2007)
• Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2007)