Saxagliptin

• Catalog No.: S143500
• CAS Number: 361442-04-8
• M. F.: C18H25N3O2
• M. W.: 315.41
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (1S,3R,5S)-2-[(2S)-2-amino-2-[(1r,3R,5R,7S)-3-hydroxyadamantan-1-yl]acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
• IUPAC Traditional name: (1S,3R,5S)-2-[(2S)-2-amino-2-[(1r,3R,5R,7S)-3-hydroxyadamantan-1-yl]acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
• Synonyms: BMS 477118-11; BMS 477118; (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; Onglyza

DATABASE IDS

• CAS Number: 361442-04-8

PROPERTIES

• Apperance: White Solid
• Melting Point: 107-110°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once da

REFERENCES

• Feng, J., et al.: J. Med. Chem., 50, 2297 (2007)
• Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2007)
• Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2007)