SANT-1

• Catalog No.: S115000
• CAS Number: 304909-07-7
• M. F.: C23H27N5
• M. W.: 373.49398
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (NE)-4-benzyl-N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylidene]piperazin-1-amine
• IUPAC Traditional name: (NE)-4-benzyl-N-[(3,5-dimethyl-1-phenylpyrazol-4-yl)methylidene]piperazin-1-amine
• Synonyms: N-[(3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine

DATABASE IDS

• CAS Number: 304909-07-7

PROPERTIES

• Apperance: Pale Yellow Solid
• Melting Point: 109-111°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cells) that acts by binding to smoothened (Smo: KD=1.2 nM), a distant relative of G protein-coupled receptors. In contrast to cyclopamine, SN

REFERENCES

• Chen, J.K., et al.: Proc. Natl. Acad. Sci. USA, 99, 14071 (2002)
• Frank-Kamenetsky, M., et al.: J. Biol. 1, 10 (2002)