(5R)-Rupintrivir

• Catalog No.: R701690
• M. F.: C31H39FN4O7
• M. W.: 598.6623632
• Storage: -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: ethyl (2E,4S)-4-[(2R,5R)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[(5-methyl-1,2-oxazol-3-yl)formamido]-4-oxoheptanamido]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate
• IUPAC Traditional name: ethyl (2E,4S)-4-[(2R,5R)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[(5-methyl-1,2-oxazol-3-yl)formamido]-4-oxoheptanamido]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate
• Synonyms: (2E,4S)-4-[[(2R,5R)-2-[(4-Fluorophenyl)methyl]-6-methyl-5-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-1,4-dioxoheptyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid

PROPERTIES

• Apperance: Off-white solid
• Melting Point: 138-140°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

The 5R-enantiomer of Rupintrivir (R701700). Rupintrivir (formerly AG7088) is an irreversible inhibitor of the human rhinovirus (HRV) 3C protease that has been demonstrated to have in vitro activity against all HRVs tested, consistent with its interaction

REFERENCES

• Arruda, E., et al.: J. Clin. Microbiol., 35, 2864 ( 1997), Dragovich, P., et al.: J. Med. Chem., 42, 1213 (1999)
• Kaiser, L., et al.: Antivir. Res., 47, 215 (1999)
• Binford, S., et al.: Antimicrob. Agents Chemother., 49, 619 (1999)
• Schmidtke, M., et al.: