Ruboxistaurin Hydrochloride

• Catalog No.: R701525
• CAS Number: 169939-93-9
• M. F.: C20H15N3O6
• M. W.: 393.3496

SYNONYMS

• IUPAC name: (19S)-19-ethyl-19-hydroxy-8-nitro-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• IUPAC Traditional name: (19S)-19-ethyl-19-hydroxy-8-nitro-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• Synonyms: (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-Dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione Hydrochloride; LY 333531

DATABASE IDS

• CAS Number: 169939-93-9

DETAILS

Description (English)

Ruboxistaurin is a protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). Ruboxistaurin is used in treatment of

REFERENCES

• Miller, J., et al.: Diabetes Metab. Rev., 13, 37 (1997)
• Suzuma, I., et al.: J. Biol. Chem., 277, 1047 (1997)
• Ali, N., et al.: J. Pharmacol. Sci., 98, 130 (1997)