SC-514

• Catalog No.: S199900
• CAS Number: 354812-17-2
• M. F.: C9H8N2OS2
• M. W.: 224.30262

SYNONYMS

• IUPAC name: 3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide
• IUPAC Traditional name: 3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide
• Synonyms: 5-(Thien-3-yl)-3-aminothiophene-2-carboxamide; 4-Amino-[2,3'-bithiophene]-5-carboxamide

DATABASE IDS

• CAS Number: 354812-17-2

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: 209-211°C
• Solubility: DMSO

DETAILS

Description (English)

A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 μM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 μM). Shown to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.

REFERENCES

• Kishore, N., et al.: J. Biol. Chem., 278, 32861 (2003)