SC-51089

• Catalog No.: S199860
• CAS Number: 146033-02-5
• M. F.: C22H20Cl2N4O3
• M. W.: 459.3252
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: N'-{6-chloro-2-oxa-9-azatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3(8),4,6,12,14-hexaene-9-carbonyl}-3-(pyridin-4-yl)propanehydrazide hydrochloride
• IUPAC Traditional name: N'-{6-chloro-2-oxa-9-azatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3(8),4,6,12,14-hexaene-9-carbonyl}-3-(pyridin-4-yl)propanehydrazide hydrochloride
• Synonyms: 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic Acid 2-[1-Oxo-3-(4-pyridinyl)propyl]hydrazide Hydrochloride; SC 51089

DATABASE IDS

• CAS Number: 146033-02-5

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 162-164°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A selective EP1 prostanoid receptor antagonist that attenuates prostaglandin E2-induced neuronal cell death in vitro and slows tumor growth in vivo. Its neuroprotective effect may potentially have therapeutic application in human stroke.

REFERENCES

• Abramovitz, M. et al.: Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1483, 285 (2000)
• Abe, T. et al.: J. Cereb. Blood Flow Metab., 29, 66 (2000)
• Fukumota, K. et al.: Eur. J. Pharmacol., 640, 82 (2000)