SB 612111 Hydrochloride

• Catalog No.: S154750
• M. F.: C24H30Cl3NO
• M. W.: 454.8601

SYNONYMS

• IUPAC name: (5S,7S)-7-{[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl}-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol hydrochloride
• IUPAC Traditional name: (5S,7S)-7-{[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl}-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol hydrochloride
• Synonyms: (5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol Hydrochloride; (-)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol Hydrochloride

DETAILS

Description (English)

A selective nociceptin/orphanin FQ receptor antagonist. A potentially useful adjunct to chronic pain therapy with opioids and can be used to treat conditions in which thermal hyperalgesia is a significant component of the pain response.

REFERENCES

• Rizzi, A. et al.: J. Pharmacol. Exp. Therap., 321, 968 (2007)
• Liao, Y. et al.: Eur. J. Pharmacol., 657, 84 (2007)
• Zaratin. P.F. et al.: J. Pharmacol. Exp. Therap., 308, 454 (2007)