Rilpivirine-d6

• Catalog No.: R509802
• CAS Number: 1312424-26-2
• M. F.: C22H18N6
• M. W.: 366.41852
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 4-{[4-({4-[(1E)-2-cyanoeth-1-en-1-yl]-2,6-bis(^2H₃)methylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile
• IUPAC Traditional name: 4-{[4-({4-[(1E)-2-cyanoeth-1-en-1-yl]-2,6-bis(^2H₃)methylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile
• Synonyms: R 278474-d6; 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-(dimethyl-d6)phenyl]amino]-2-pyrimidinyl]amino]benzonitrile; TMC 278-d6

DATABASE IDS

• CAS Number: 1312424-26-2

PROPERTIES

• Apperance: Off-White to Pale Yellow Solid
• Melting Point: 238-243°C
• Solubility: DMSO
• Solubility: Methanol (Sparingly)
• Storage Condition: Refrigerator

DETAILS

Description (English)

A labelled novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.

REFERENCES

• Sun, et al.: J. Med. Chem., 41, 4648 (1998)
• Kashiwada, et al.: Bioorg. Med. Chem. Lett., 11, 183 (1998)