Ridaforolimus, >80%

• Catalog No.: R495850
• CAS Number: 572924-54-0
• M. F.: C53H84NO14P
• M. W.: 990.206121
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30R,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl dimethylphosphinate
• IUPAC Traditional name: (1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30R,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl dimethylphosphinate
• Synonyms: AP 23573; MK 8669; Deforolimus; Rapamycin 42-(Dimethylphosphinate)

DATABASE IDS

• CAS Number: 572924-54-0

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 95-98°C
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

An immunosupressant and is currently being investigated for use in cancer treatments. Ridaforolimus may act as a regulator of protein synthesis, cell proliferation, cell cycle progression and cell survival. Ridaforolimus, was formerly known as Deforolimus

REFERENCES

• Gadducci, A., et al.: Gynecol. Endocrinol., 24, 239 (2008)
• Gridelli, C., et al.: Oncol., 13, 139 (2008)
• Mita, M., et al.: J. Clin. Oncol., 26, 361 (2008)
• Hartford, C., et al.: Clin. Canc. Res., 15, 1428 (2008)