Romidepsin-d8

• Catalog No.: R425062
• M. F.: C24H36N4O6S2
• M. W.: 540.69584

SYNONYMS

• IUPAC name: (1S,4S,7Z,16E,21R)-7-ethylidene-21-(propan-2-yl)-4-[(^2H₇)propan-2-yl](4-^2H)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
• IUPAC Traditional name: (1S,4S,7Z,16E,21R)-7-ethylidene-21-isopropyl-4-[(^2H₇)propan-2-yl](4-^2H)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
• Synonyms: [S-(E)]-N-(3-Hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-didehydro-2-aminobutanoyl-L-valine (4-1)-Lactone-d8 Cyclic (12)-Disulfide; Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl]-d8 Cyclic (35)-Disulfide; FR 901228-d8; Chromadax-d8; Antibiotic FR 901228-d8; FK 228-d8; NSC 630176-d8

DETAILS

Description (English)

Labelled Romidepsin (R425060). Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibi

REFERENCES

• Ueda, H., et al.: J. Antibiot., 47, 301 (1994)
• Weidle, U., et al.: Anticancer Res., 20, 1471 (1994)
• Kitazono, M., et al.: Cancer Res., 61, 6328 (1994)
• Sandor, V., et al.: Clin. Cancer Res., 8, 718 (1994)