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Romidepsin

Catalog No. R425060 Name Toronto Research Chemicals
CAS Number 128517-07-7 Website http://www.trc-canada.com
M. F. C24H36N4O6S2 Telephone +1 (416) 665-9696
M. W. 540.69584 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Amber Vial, -20°C Freezer, Under Inert Atmosphere Chembase ID: 177529

SYNONYMS

IUPAC name
(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
IUPAC Traditional name
romidepsin
Synonyms
Chromadax
FK 228
Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl] Cyclic (35)-Disulfide
[S-(E)]-N-(3-Hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-didehydro-2-aminobutanoyl-L-valine (4-1)-Lactone Cyclic (12)-Disulfide
Antibiotic FR 901228
FR 901228
NSC 630176

DATABASE IDS

CAS Number 128517-07-7

PROPERTIES

Apperance Pale Yellow Solid
Melting Point 219-224°C
Solubility Chloroform
MSDS Link Download
Storage Condition Amber Vial, -20°C Freezer, Under Inert Atmosphere
Certificate of Analysis Download

DETAILS

Description (English)
Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibition. Romidepsin has shown anti

REFERENCES

  • Ueda, H., et al.: J. Antibiot., 47, 301 (1994)
  • Weidle, U., et al.: Anticancer Res., 20, 1471 (1994)
  • Kitazono, M., et al.: Cancer Res., 61, 6328 (1994)
  • Sandor, V., et al.: Clin. Cancer Res., 8, 718 (1994)