Resatorvid

• Catalog No.: R144570
• CAS Number: 243984-11-4
• M. F.: C15H17ClFNO4S
• M. W.: 361.8161832

SYNONYMS

• IUPAC name: ethyl (6S)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate
• IUPAC Traditional name: ethyl (6S)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate
• Synonyms: (6R)-6-[[(2-Chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic Acid Ethyl Ester; TAK 242

DATABASE IDS

• CAS Number: 243984-11-4

DETAILS

Description (English)

Resatorvid is a novel selective Toll-like receptor 4 signal transduction inhibitor. Resatorvid inhibits various kinds of inflammatory mediators such as nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, IL-10, macrophage inhibitor

REFERENCES

• Abraham, E., et al.: Lancet, 351, 929 (1998)
• Akashi, S., et al.: J. Exp. Med., 198, 1035 (1998)
• Akira, S., et al.: Immunol. Lett., 85, 85 (1998)
• Medvedev, A., et al.: J. Biol. Chem., 282, 16042 (1998)