(19E/Z)-seco Rapamycin Sodium Salt, >85% By HPLC

• Catalog No.: R124010
• M. F.: C51H78NNaO13
• M. W.: 936.15369
• Storage: Amber Vial, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: sodium (2R)-1-{2-[(2R,3R,6R)-2-hydroxy-6-[(3E,5E,7E,9S,11R,13S,14R,15E,17R,19E,21R)-14-hydroxy-22-[(1S,3S,4R)-4-hydroxy-3-methoxycyclohexyl]-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaen-1-yl]-3-methyloxan-2-yl]-2-oxoacetyl}piperidine-2-carboxylate
• IUPAC Traditional name: sodium (2R)-1-{2-[(2R,3R,6R)-2-hydroxy-6-[(3E,5E,7E,9S,11R,13S,14R,15E,17R,19E,21R)-14-hydroxy-22-[(1S,3S,4R)-4-hydroxy-3-methoxycyclohexyl]-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaen-1-yl]-3-methyloxan-2-yl]-2-oxoacetyl}piperidine-2-carboxylate
• Synonyms: [2R-[2α,2(S*),3α,6β[2S*,3E,5E,7E,9S*,11R*,13R*,14R*,15E,17R*,19E/Z,21R*,22(1S*,3R*,4R*)]]]-1-[Oxo[tetrahydro-2-hydroxy-6-[14-hydroxy-22-(4-hydroxy-3-methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxo-3,5,7,15,19-docosapentaenyl]-3-methyl-2H-pyran-2-yl]acetyl]-2-piperidinecarboxylic Acid Monosodium Salt

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: 120-122°C
• Solubility: Methanol
• Solubility: Water
• Storage Condition: Amber Vial, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A decomposition product of Rapamycin (R124000).

REFERENCES

• Yatscoff, R.W., et all.: Ther. Drug Monit., 17, 666 (1995)
• Wacher, V.J., et al.: J. Pharm. Sci., 87, 1322 (1995)