Rapamycin-d3 (contains d0) Technical Grade

• Catalog No.: R124002
• M. F.: C51H79NO13
• M. W.: 914.17186
• Storage: -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30R,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-30-(^2H₃)methoxy-19-methoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
• IUPAC Traditional name: (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30R,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-30-(^2H₃)methoxy-19-methoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
• Synonyms: Rapammune-d3; NSC 226080-d3; Antibiotic AY 22989-d3; Cypher-d3; (-)-Rapamycin-d3; RAPA-d3; AY 22989-d3; RPM-d3; Rapamune-d3; SIIA 9268A-d3; Sirolimus-d3; Wy 090217-d3

PROPERTIES

• Apperance: Off-White to Pale-Yellow Solid
• Melting Point: 101-103°C
• Solubility: Dichloromethane
• Solubility: Methanol
• Storage Condition: -20°C Freezer, Under Inert Atmosphere
• Storage Warning: Temperature and Moisture Sensitive

DETAILS

Description (English)

Labelled Rapamycin. A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic.This compound contains aproximately 2% d0.

REFERENCES

• Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977)
• Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1977)
• Kahan, B.D., et al.: Lancet, 356, 194 (1977)
• Holmes, D.R., et al.: Circulation, 109, 634 (1977)