Pravastatin-d3 Sodium Salt

• Catalog No.: P702002
• M. F.: C23H35NaO7
• M. W.: 446.50957
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: sodium (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2R)-2-(^2H₃)methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
• IUPAC Traditional name: sodium (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2R)-2-(^2H₃)methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
• Synonyms: Mevalotin-d3; βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-(methyl-d3)-1-oxobutoxy]-1-naphthaleneheptanoic Acid Sodium Salt; Pravaselect-d3; Pravachol-d3; Elisor-d3; Kopostat-d3

PROPERTIES

• Apperance: White Solid
• Melting Point: 160-164°C (dec.)
• Solubility: Methanol
• Solubility: Water
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A stable isotope of Pravastatin, a competitive inhibitor of HMG-CoA reductase. Bioactive metabolite of Mevastatin.A representative lot is 86% d3, 13% d2 and 1% d1.

REFERENCES

• Serizawa, N., et al.: J. Antibiot., 36, 604 (1983)
• Yoshino, G., et al.: Lancet, 2, 740 (1983)
• White, H.D, et al.: N. Engl. J. Med., 343, 317 (2000)