Pracinostat-d7

• Catalog No.: P699102
• M. F.: C20H30N4O2
• M. W.: 358.4778

SYNONYMS

• IUPAC name: (2E)-3-{2-[(2,2,3,3,4,4,4-^2H₇)butyl]-1-[2-(diethylamino)ethyl]-1H-1,3-benzodiazol-5-yl}-N-hydroxyprop-2-enamide
• IUPAC Traditional name: (2E)-3-{2-[(2,2,3,3,4,4,4-^2H₇)butyl]-1-[2-(diethylamino)ethyl]-1,3-benzodiazol-5-yl}-N-hydroxyprop-2-enamide
• Synonyms: Kaempferol 3-O-β-D-(6-E-p-Coumaroylglucoside)-d7; (2E)-3-[2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-2-propenamide-d7; SB939-d7; (E)-3-[2-Butyl-1-(2-diethylaminoethyl)-1H-benzimidazol-5-yl]-N-hydroxy-2-propenamide-d7; (2E)-3-[2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxyacrylamide-d7; SB 939-d7

DETAILS

Description (English)

Labelled Pracinostat. Pracinostat is a potent and orally active histone deacetylase (HDAC) inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. The selectivity of Pracinostat for tumor tissues makes it a promising therapeu

REFERENCES

• Novotny-Diermayr, V. et al.: Mol. Cancer Therap., 9, 642 (2010)
• Razak, A.R.A. et al.: Br. J. Cancer, 104, 756 (2010)
• Novotny-Diermayr, V. et al.: Mol. Cancer Therap., 10, 1207 (2010)