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Ponatinib

Catalog No. P688250 Name Toronto Research Chemicals
CAS Number 943319-70-8 Website http://www.trc-canada.com
M. F. C29H27F3N6O Telephone +1 (416) 665-9696
M. W. 532.5594896 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Amber Vial, Refrigerator, Under inert atmosphere Chembase ID: 72711

SYNONYMS

IUPAC name
3-(2-{imidazo[1,2-b]pyridazin-3-yl}ethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide
IUPAC Traditional name
ponatinib
Synonyms
AP 24534
3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide

DATABASE IDS

CAS Number 943319-70-8

PROPERTIES

Certificate of Analysis Download
Apperance Pale Yellow Solid
Melting Point >160°C (dec.)
Solubility DMSO
Solubility Methanol
MSDS Link Download
Storage Condition Amber Vial, Refrigerator, Under inert atmosphere

DETAILS

Description (English)
Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor. Ponatinib inhibits both native and mutant BCR-ABL. Ponatinib is used in the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors.

REFERENCES

  • Weisberg, E., et al.: Cancer Cell, 7, 129 (2005)
  • Zhou, T., et al.: Chem. Biol. Drug Des., 70, 171 (2005)
  • Quintas-Cardama, A., et al.: Blood, 2009, 113, 1619 (2005)