Ponatinib

• Catalog No.: P688250
• CAS Number: 943319-70-8
• M. F.: C29H27F3N6O
• M. W.: 532.5594896
• Storage: Amber Vial, Refrigerator, Under inert atmosphere

SYNONYMS

• IUPAC name: 3-(2-{imidazo[1,2-b]pyridazin-3-yl}ethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide
• IUPAC Traditional name: ponatinib
• Synonyms: AP 24534; 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide

DATABASE IDS

• CAS Number: 943319-70-8

PROPERTIES

• Apperance: Pale Yellow Solid
• Melting Point: >160°C (dec.)
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Amber Vial, Refrigerator, Under inert atmosphere

DETAILS

Description (English)

Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor. Ponatinib inhibits both native and mutant BCR-ABL. Ponatinib is used in the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors.

REFERENCES

• Weisberg, E., et al.: Cancer Cell, 7, 129 (2005)
• Zhou, T., et al.: Chem. Biol. Drug Des., 70, 171 (2005)
• Quintas-Cardama, A., et al.: Blood, 2009, 113, 1619 (2005)