Plerixafor-d4

• Catalog No.: P580502
• CAS Number: 1246819-87-3
• M. F.: C28H54N8
• M. W.: 502.78196
• Storage: Hygroscopic, Refrigerator, Under Inert Atmosphere

SYNONYMS

• IUPAC name: 1-{[4-(1,4,8,11-tetraazacyclotetradecan-1-ylmethyl)(^2H₄)phenyl]methyl}-1,4,8,11-tetraazacyclotetradecane
• IUPAC Traditional name: 1-{[4-(1,4,8,11-tetraazacyclotetradecan-1-ylmethyl)(^2H₄)phenyl]methyl}-1,4,8,11-tetraazacyclotetradecane
• Synonyms: 1,1'-[1,4-(Phenylene-d4)bis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane

DATABASE IDS

• CAS Number: 1246819-87-3

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 100-102°C
• Solubility: Methanol
• Storage Condition: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Storage Warning: Very Hygroscopic

DETAILS

Description (English)

Labelled Plerixafor, it is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combinat

REFERENCES

• Xie, T., et al.: Science, 290, 328 (2000)
• Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2000)
• Chigaev, A., et al.: J. Immunol. 178, 6828 (2000)
• Kiel, M., et al.: Cell Stem Cell, 1, 204 (2000)