Pitavastatin-d5 Lactone

• Catalog No.: P531022
• M. F.: C25H22FNO3
• M. W.: 403.4454832
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (4R,6S)-6-[(E)-2-[2-(^2H₅)cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]ethenyl]-4-hydroxyoxan-2-one
• IUPAC Traditional name: (4R,6S)-6-[(E)-2-[2-(^2H₅)cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]ethenyl]-4-hydroxyoxan-2-one
• Synonyms: NK 104-d5 (lactone); [4R-[4α,6β(E)]]-6-[2-[2-(Cyclopropyl-d5)-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one; (4R,6S)-6-[(1E)-2-[2-(Cyclopropyl-d5)-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one; P 872441-d5; NK 104-d5; Nisvastatin-d5

PROPERTIES

• Apperance: Off-White to Pale Yellow Solid
• Melting Point: 72-75°C
• Solubility: Chloroform
• Solubility: Ethyl Acetate
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A labelled metabolite of Pitavastatin. Recent studies have shown that conversion between acid and lactone forms occurs in the body, drug-drug interaction should be considered on both acid and lactone forms. The inhibitory effects of statins on CYP metabol

REFERENCES

• Wang, J., et al.: Drug Metab. Dispos., 30, 1352 (2002)
• Yamada, I., et al.: Xenobiotica, 33, 789 (2002)
• Fujino, H., et al.: Xenobiotica, 34, 961 (2002)
• Ando, H., et al.: Br. J. Clin. Pharmacol., 60, 494 (2002)