(1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methylbutane-1-boronate-d8

• Catalog No.: P458532
• M. F.: C29H39BN4O4
• M. W.: 518.45536

SYNONYMS

• IUPAC name: (2S)-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.0^2,^6]decan-4-yl]butyl]-3-(^2H₅)phenyl-2-(pyrazin-2-ylformamido)(^2H₃)propanamide
• IUPAC Traditional name: (2S)-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.0^2,^6]decan-4-yl]butyl]-3-(^2H₅)phenyl-2-(pyrazin-2-ylformamido)(^2H₃)propanamide
• Synonyms: N-[(1S)-2-[[(1R)-1-[(3aS,4S,6S,7aR)-Hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide

PROPERTIES

• Apperance: Yellow Solid
• Solubility: Chloroform
• Solubility: Dimethyl Sulfoxide
• Solubility: Ethanol
• Solubility: Ethyl Acetate

DETAILS

Description (English)

Intermediate in the preparation of Bortezomib (B675700), a dipeptidyl boronate proteasome inhibitor.

REFERENCES

• Zhu, Y., et al.: Bioorg. Med. Chem., 14, 1483 (2006)
• Dorsey, B., et al.: J. Med. Chem., 51, 1068 (2006)
• Zhu, Y., et al.: Eur. J .Med. Chem., 44, 1486 (2006)