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(1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate_Molecular_structure_CAS_205393-22-2)
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(1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate

Catalog No. P458530 Name Toronto Research Chemicals
CAS Number 205393-22-2 Website http://www.trc-canada.com
M. F. C29H39BN4O4 Telephone +1 (416) 665-9696
M. W. 518.45536 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage -20°C Freezer Chembase ID: 176735

SYNONYMS

IUPAC name
(2S)-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-3-phenyl-2-(pyrazin-2-ylformamido)propanamide
IUPAC Traditional name
(2S)-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-3-phenyl-2-(pyrazin-2-ylformamido)propanamide
Synonyms
N-[(1S)-2-[[(1R)-1-[(3aS,4S,6S,7aR)-Hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide

DATABASE IDS

CAS Number 205393-22-2

PROPERTIES

Certificate of Analysis Download
Apperance Yellow Solid
Melting Point 75-83°C
Solubility Chloroform
Solubility Dimethyl Sulfoxide
Solubility Ethanol
Solubility Ethyl Acetate
MSDS Link Download
Storage Condition -20°C Freezer

DETAILS

Description (English)
Intermediate in the preparation of Bortezomib (B675700), a dipeptidyl boronate proteasome inhibitor.

REFERENCES

  • Zhu, Y., et al.: Bioorg. Med. Chem., 14, 1483 (2006)
  • Dorsey, B., et al.: J. Med. Chem., 51, 1068 (2006)
  • Zhu, Y., et al.: Eur. J .Med. Chem., 44, 1486 (2006)