Pimecrolimus

• Catalog No.: P445000
• CAS Number: 137071-32-0
• M. F.: C43H68ClNO11
• M. W.: 810.45312
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25R,27R)-12-[(1E)-1-[(1R,3S,4S)-4-chloro-3-methoxycyclohexyl]prop-1-en-2-yl]-17-ethyl-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0^4,^9]octacos-18-ene-2,3,10,16-tetrone
• IUPAC Traditional name: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25R,27R)-12-[(1E)-1-[(1R,3S,4S)-4-chloro-3-methoxycyclohexyl]prop-1-en-2-yl]-17-ethyl-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0^4,^9]octacos-18-ene-2,3,10,16-tetrone
• Synonyms: SDZ-ASM 981; Picrolimus; 33-epi-Chloro-33-desoxyascomycin; Elidel; 33-Epichloro-33-desoxyascomycin; ASM 981

DATABASE IDS

• CAS Number: 137071-32-0

PROPERTIES

• Apperance: White Solid
• Melting Point: 142-144°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Macrolactam ascomycin derivative; inhibits production of pro-inflammatory cytokines by T cells and mast cells. Immunosuppresant.

REFERENCES

• Gassberger, M., et al.: Br. J. Dermatol., 141, 264 (1999)
• Queille-Roussel, C., et al.: Contact Dermatitis, 42, 349 (1999)