PHA-665752 Hydrate

• Catalog No.: P294425
• M. F.: C32H34Cl2N4O4S
• M. W.: 641.60776

SYNONYMS

• IUPAC name: (3Z)-5-[(2,6-dichlorophenyl)methanesulfonyl]-3-({3,5-dimethyl-4-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]-1H-pyrrol-2-yl}methylidene)-2,3-dihydro-1H-indol-2-one
• IUPAC Traditional name: (3Z)-5-[(2,6-dichlorophenyl)methanesulfonyl]-3-({3,5-dimethyl-4-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]-1H-pyrrol-2-yl}methylidene)-1H-indol-2-one
• Synonyms: (3Z)-5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one Hydrate; PHA 665752 Hydrate

DETAILS

Description (English)

PHA-665752 ia a c-Met kinase inhibitor. PHA-665752 is ATP-competitive, an active-site inhibitor with greater than 50-fold selectivity for c-Met vs a panel of tyrosine and serine-threonine kinases.

REFERENCES

• Cheng, H., et al.: J. Clin. Oncol., 20, 1544 (2002)
• Ma, P., et al.: Cancer Metastasis Rev., 22, 309 (2002)
• Christensen, J., et al.: Cancer Lett., 225, 1 (2002)
• Lo Muzio, L., et al.: Tumor Biol., 27, 116 (2002)