PHA-543613 Dihydrochloride

• Catalog No.: P294400
• CAS Number: 478148-58-2
• M. F.: C15H17N3O2
• M. W.: 271.31438
• Storage: Refrigerator

SYNONYMS

• IUPAC name: N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide
• IUPAC Traditional name: N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide
• Synonyms: PHA 543613E; N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide Dihydrochloride

DATABASE IDS

• CAS Number: 478148-58-2

PROPERTIES

• Apperance: Tan Solid
• Melting Point: >300°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

PHA-543613 is a potent selective α7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression in brain. The homomeric subtype α7 is a potential ther

REFERENCES

• Shaffer, C.L. et al.: Drug Metab. Dispos., 35, 1188 (2007)
• Wishka, D.G. et al.: J. Med. Chem., 49, 4425 (2007)
• Acker, B.A. et al.: Bioorg. Med. Chem. Lett., 18, 3611 (2007)