PF-4942847

• Catalog No.: P294025
• CAS Number: 1207961-33-8
• M. F.: C22H23ClF3N7O2
• M. W.: 509.9119296

SYNONYMS

• IUPAC name: 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5H,6H,7H-pyrrolo[3,4-d]pyrimidine-6-carboxamide
• IUPAC Traditional name: 2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5H,7H-pyrrolo[3,4-d]pyrimidine-6-carboxamide
• Synonyms: PF04942847; 2-Amino-4-[4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl]-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide

DATABASE IDS

• CAS Number: 1207961-33-8

DETAILS

Description (English)

A novel potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitor of heat shock protein 90 (Hsp90). It has been shown to induce degradation of multiple client proteins, cell-cycle block, apoptosis, and inhibits cell proliferati

REFERENCES

• Zehnder, L. et al.: J. Med. Chem., 54, 3368 (2011)
• Mehta, P.P. et al.: Clin. Cancer Res., 17, 5432 (2011)
• Yamakazi, S. et al.: J. Pharmacol. Exp. Therap., 338, 964 (2011)