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PF-4708671 _Molecular_structure_CAS_1255517-76-0)
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PF-4708671

Catalog No. P294010 Name Toronto Research Chemicals
CAS Number 1255517-76-0 Website http://www.trc-canada.com
M. F. C19H21F3N6 Telephone +1 (416) 665-9696
M. W. 390.4054496 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage -20°C Freezer Chembase ID: 154750

SYNONYMS

IUPAC name
2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-1,3-benzodiazole
IUPAC Traditional name
2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-1,3-benzodiazole
Synonyms
PF 4708671
2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole

DATABASE IDS

CAS Number 1255517-76-0

PROPERTIES

Certificate of Analysis Download
Apperance Pale purple Solid
Melting Point 189-191°C
Solubility DMSO
Solubility Methanol
MSDS Link Download
Storage Condition -20°C Freezer

DETAILS

Description (English)
PF-4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). PF-4708671 inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect on highly related RSK (p90 ribosomal S

REFERENCES

  • Pearce, L.R. et al.: Biochem. J., 431, 245 (2010)