PF-573228 _Molecular_structure_CAS_869288-64-2)

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PF-573228
Catalog No.	P293950	Name	Toronto Research Chemicals
CAS Number	869288-64-2	Website	http://www.trc-canada.com
M. F.	C22H20F3N5O3S	Telephone	+1 (416) 665-9696
M. W.	491.4861096	Fax	+1 (416) 665-4439
Purity		Email	info@trc-canada.com
Storage	Refrigerator	Chembase ID: 154608

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SYNONYMS

IUPAC name

6-[(4-{[(3-methanesulfonylphenyl)methyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl)amino]-1,2,3,4-tetrahydroquinolin-2-one

IUPAC Traditional name

6-[(4-{[(3-methanesulfonylphenyl)methyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one

Synonyms

PF 573228

6-[(4-((3-(Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one

3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone

DATABASE IDS

CAS Number

869288-64-2

PROPERTIES

Certificate of Analysis	Download
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Storage Condition	Refrigerator

DETAILS

Description (English)

A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells.

REFERENCES

Slack-Davis, J.K. et al.: J. Biol. Chem., 282, 14845 (2007)
Hiscox, S. et al.: Breast Cancer Res. Treat., 125, 659 (2007)