PF-514273

• Catalog No.: P293900
• CAS Number: 851728-60-4
• M. F.: C21H17Cl2F2N3O2
• M. W.: 452.2813864
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-2H,5H,6H,7H,8H-pyrazolo[3,4-f][1,4]oxazepin-8-one
• IUPAC Traditional name: 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-5H,6H-pyrazolo[3,4-f][1,4]oxazepin-8-one
• Synonyms: 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one; PF 514273

DATABASE IDS

• CAS Number: 851728-60-4

PROPERTIES

• Apperance: White Solid
• Melting Point: 158-160°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity.

REFERENCES

• Hao, S., et al.: Eur. J. Pharmacol., 392, 147 (2000)
• Kershaw, E., et al.: J. Clin. Endocrinol. Metab., 89, 2548 (2000)
• Engeli, S., et al.: Diabetes, 54, 2838 (2000)
• Lin, L., et al.: J. Med. Chem., 49, 7584 (2000)