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PF 477736_Molecular_structure_CAS_952021-60-2)
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PF 477736

Catalog No. P293850 Name Toronto Research Chemicals
CAS Number 952021-60-2 Website http://www.trc-canada.com
M. F. C22H25N7O2 Telephone +1 (416) 665-9696
M. W. 419.4796 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Chembase ID: 155048

SYNONYMS

IUPAC name
(2R)-2-amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7,11-pentaen-6-yl]acetamide
IUPAC Traditional name
(2R)-2-amino-2-cyclohexyl-N-[2-(1-methylpyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7,11-pentaen-6-yl]acetamide
Synonyms
(αR)-α-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]cyclohexaneacetamide

DATABASE IDS

CAS Number 952021-60-2

PROPERTIES

Certificate of Analysis Download
MSDS Link Download

DETAILS

Description (English)
P293850 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage.

REFERENCES

  • Ashwell, et al.: Clin. Cancer Res., 14, 4032 (2008)
  • Blasina, et al.: Mol. Cancer Ther., 7 2394 (2008)
  • Zhang, et al.: Clin. Cancer Res., 15 4630 (2008)