PF 477736

• Catalog No.: P293850
• CAS Number: 952021-60-2
• M. F.: C22H25N7O2
• M. W.: 419.4796

SYNONYMS

• IUPAC name: (2R)-2-amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0^4,^1^3]trideca-1,4(13),5,7,11-pentaen-6-yl]acetamide
• IUPAC Traditional name: (2R)-2-amino-2-cyclohexyl-N-[2-(1-methylpyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0^4,^1^3]trideca-1,4(13),5,7,11-pentaen-6-yl]acetamide
• Synonyms: (αR)-α-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]cyclohexaneacetamide

DATABASE IDS

• CAS Number: 952021-60-2

DETAILS

Description (English)

P293850 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage.

REFERENCES

• Ashwell, et al.: Clin. Cancer Res., 14, 4032 (2008)
• Blasina, et al.: Mol. Cancer Ther., 7 2394 (2008)
• Zhang, et al.: Clin. Cancer Res., 15 4630 (2008)