PF-3644022

• Catalog No.: P293825
• CAS Number: 1276121-88-0
• M. F.: C22H25N7O2
• M. W.: 419.4796

SYNONYMS

• IUPAC name: (2R)-2-amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0^4,^1^3]trideca-1,4(13),5,7,11-pentaen-6-yl]acetamide
• IUPAC Traditional name: (2R)-2-amino-2-cyclohexyl-N-[2-(1-methylpyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0^4,^1^3]trideca-1,4(13),5,7,11-pentaen-6-yl]acetamide
• Synonyms: (10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one

DATABASE IDS

• CAS Number: 1276121-88-0

DETAILS

Description (English)

PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated

REFERENCES

• Hegen, M., et al.: J. Immunol., 177, 1913 (2006)
• Anderson, D., et al.: J. Med. Chem., 50, 2647 (2006)
• Goldberg, D., et al.: Bioorg. Med. Chem. Lett., 18, 938 (2006)
• Burnette, B., et al.: Pharmacology, 84, 42 (2006)
• Mourey, et al.: J. Pharmacol. Exp. T